Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1994 1
1995 1
1996 3
1997 3
1998 12
1999 19
2000 16
2001 32
2002 30
2003 52
2004 67
2005 86
2006 97
2007 120
2008 128
2009 153
2010 155
2011 214
2012 182
2013 183
2014 203
2015 197
2016 169
2017 163
2018 160
2019 160
2020 148
2021 141
2022 87
2023 79
2024 43

Text availability

Article attribute

Article type

Publication date

Search Results

2,717 results

Results by year

Filters applied: . Clear all
Page 1
The chemokines CXCL8 and CXCL12: molecular and functional properties, role in disease and efforts towards pharmacological intervention.
Cambier S, Gouwy M, Proost P. Cambier S, et al. Cell Mol Immunol. 2023 Mar;20(3):217-251. doi: 10.1038/s41423-023-00974-6. Epub 2023 Feb 1. Cell Mol Immunol. 2023. PMID: 36725964 Free PMC article. Review.
CXCL8 activity inherently depends on interaction with the human CXC chemokine receptors CXCR1 and CXCR2, the atypical chemokine receptor ACKR1, and glycosaminoglycans. ...CXCL8-mediated neutrophil mobilization to blood is directly opposed by CXCL12, which ret …
CXCL8 activity inherently depends on interaction with the human CXC chemokine receptors CXCR1 and CXCR2, the atypical chemokine …
Stromal cell-derived factor-1 (CXCL12) and its role in bone and muscle biology.
Gilbert W, Bragg R, Elmansi AM, McGee-Lawrence ME, Isales CM, Hamrick MW, Hill WD, Fulzele S. Gilbert W, et al. Cytokine. 2019 Nov;123:154783. doi: 10.1016/j.cyto.2019.154783. Epub 2019 Jul 20. Cytokine. 2019. PMID: 31336263 Free PMC article. Review.
Thus, it is important to better understand the underlying pathologic mechanisms of the disease process. Regulatory chemokine, CXCL12, and its receptor, CXCR4, are recognized to be essential in the recruitment, localization, maintenance, development and differentiati …
Thus, it is important to better understand the underlying pathologic mechanisms of the disease process. Regulatory chemokine, CXCL …
CXCL12 and CXCR4 in bone marrow physiology.
Moll NM, Ransohoff RM. Moll NM, et al. Expert Rev Hematol. 2010 Jun;3(3):315-22. doi: 10.1586/ehm.10.16. Expert Rev Hematol. 2010. PMID: 21082982 Review.
This article discusses the multiple roles of CXCL12 and its receptor, CXCR4, in bone marrow (BM) hematopoietic stem cell (HSC) development and regulation. CXCL12 interaction with CXCR4 results in effects as varied as cell migration, proliferation and survival …
This article discusses the multiple roles of CXCL12 and its receptor, CXCR4, in bone marrow (BM) hematopoietic stem cell (HSC) …
The bone-liver interaction modulates immune and hematopoietic function through Pinch-Cxcl12-Mbl2 pathway.
He T, Zhou B, Sun G, Yan Q, Lin S, Ma G, Yao Q, Wu X, Zhong Y, Gan D, Huo S, Jin W, Chen D, Bai X, Cheng T, Cao H, Xiao G. He T, et al. Cell Death Differ. 2024 Jan;31(1):90-105. doi: 10.1038/s41418-023-01243-9. Epub 2023 Dec 7. Cell Death Differ. 2024. PMID: 38062244
We find that Pinch is critical for expression of Cxcl12 in BMSCs; reduced production of Cxcl12 protein from Pinch-deficient BMSCs reduces expression of the Mbl2 complement in hepatocytes, thus impairing the innate immunity and thereby contributing to infection and d …
We find that Pinch is critical for expression of Cxcl12 in BMSCs; reduced production of Cxcl12 protein from Pinch-deficient BM …
Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches.
Ding L, Morrison SJ. Ding L, et al. Nature. 2013 Mar 14;495(7440):231-5. doi: 10.1038/nature11885. Epub 2013 Feb 24. Nature. 2013. PMID: 23434755 Free PMC article.
This raises the fundamental question of whether HSCs and restricted progenitors reside within distinct, specialized niches or whether they share a common niche. Here we assess the physiological sources of the chemokine CXCL12 for HSC and restricted progenitor mainte …
This raises the fundamental question of whether HSCs and restricted progenitors reside within distinct, specialized niches or whether they s …
The CXCL12-CXCR4/CXCR7 axis as a mechanism of immune resistance in gastrointestinal malignancies.
Daniel SK, Seo YD, Pillarisetty VG. Daniel SK, et al. Semin Cancer Biol. 2020 Oct;65:176-188. doi: 10.1016/j.semcancer.2019.12.007. Epub 2019 Dec 23. Semin Cancer Biol. 2020. PMID: 31874281 Review.
High levels of CXCL12 seen in the bone marrow, liver, and spleen could partially explain why these are popular sites of metastases for many tumors. ...Other small molecules and monoclonal antibodies against CXCR4 are being trialed. Further understanding of the CX …
High levels of CXCL12 seen in the bone marrow, liver, and spleen could partially explain why these are popular sites of metast …
The role of the CXCL12-CXCR4/CXCR7 axis in the progression and metastasis of bone sarcomas (Review).
Liao YX, Zhou CH, Zeng H, Zuo DQ, Wang ZY, Yin F, Hua YQ, Cai ZD. Liao YX, et al. Int J Mol Med. 2013 Dec;32(6):1239-46. doi: 10.3892/ijmm.2013.1521. Epub 2013 Oct 11. Int J Mol Med. 2013. PMID: 24127013 Review.
Chemokine 12 (CXCL12), also designated as stromal cell-derived factor-1 (SDF-1), is able to bind to its cognate receptors, chemokine receptor 4 (CXCR4) and chemokine receptor 7 (CXCR7), with high affinity. ...In addition, we review the involvement of t …
Chemokine 12 (CXCL12), also designated as stromal cell-derived factor-1 (SDF-1), is able to bind to its cognate receptors, …
Chemokines and bone remodeling.
Galliera E, Locati M, Mantovani A, Corsi MM. Galliera E, et al. Int J Immunopathol Pharmacol. 2008 Jul-Sep;21(3):485-91. doi: 10.1177/039463200802100301. Int J Immunopathol Pharmacol. 2008. PMID: 18831915 Free article. Review.
Bone remodeling is characterized by spatial and temporal coupling of bone resorption and formation and is necessary for skeletal growth and normal bone structure maintenance. ...This review focuses on the role of inflammatory mediators, such as cytokines in …
Bone remodeling is characterized by spatial and temporal coupling of bone resorption and formation and is necessary for skelet …
Damage and recovery of the bone marrow microenvironment induced by cancer chemotherapy - potential regulatory role of chemokine CXCL12/receptor CXCR4 signalling.
Georgiou KR, Foster BK, Xian CJ. Georgiou KR, et al. Curr Mol Med. 2010 Jul;10(5):440-53. doi: 10.2174/156652410791608243. Curr Mol Med. 2010. PMID: 20540706 Review.
However, depending on the dosage and length of chemotherapy treatment, complications in bone and bone marrow recovery occur. This may manifest as marrow haematopoietic depletion, high marrow fat content, reduced bone formation and aggravated osteoclastic b …
However, depending on the dosage and length of chemotherapy treatment, complications in bone and bone marrow recovery occur. T …
2,717 results